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Autoantibody Associated Condition
ANA (antinuclear antibody) SLE, MCTD, SSc, PM, DM, SjS, RA, aging
ACPA (anti-citrullinated protein antibody) or CCP (cyclic citrullinated peptides) RA, PsA, TB
dsDNA SLE
Sm (Smith) SLE
Ro (SS-A) SjS, SLE
La (SS-B) SjS, SLE
Centromere lcSSc (CREST syndrome), PBC
Scl-70 (topoisomerase I) dcSSc
Jo-1 (histidyl-tRNA synthetase) PM/DM
PL-7 (threonyl-tRNA synthetase) PM/DM with ILD
PM/Scl (exosome complex) PM-SSc overlap syndrome
C1q Hypocomplementemic urticarial vasculitis
aCL (anti-cardiolipin antibody) APS
β2GI (β2-glycoprotein I) APS
LA (lupus anticoagulant) APS
U1-RNP (snRNP70, U1 small nuclear ribonucleoprotein 70 kDa) MCTD
RF (rheumatoid factor) RA, SLE, SSc, MCTD, SjS, PM, cryoglobulinemia, HIV, TB, chronic infection, sarcoidosis, malignancy
Low C3, C4 Cryoglobulinemia, MPGN, PSGN, SLE, RA, urticarial vasculitis, subacute bacterial endocarditis
Cryoglobulins Cryoglobulinemia
c-ANCA (cytoplasmic anti-neutrophil cytoplasm antibody), PR3 ⊕ Microscopic polyangiitis, Churg-Strauss syndrome, Wegener granulomatosis
p-ANCA (perinuclear anti-neutrophil cytoplasm antibody), MPO ⊕ Microscopic polyangiitis, Churg-Strauss syndrome, Wegener granulomatosis
p-ANCA (perinuclear anti-neutrophil cytoplasm antibody), MPO ⊖ UC, autoimmune hepatitis, RA, SLE, HIV, chronic infection, malignancy

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